Careers

Lab Manager

Process Development (PD) and GMP Manufacturing Group

Vyriad is a clinical stage biotechnology company focused on curing cancer using oncolytic viruses designed to selectively and rapidly destroy cancer. The PD and GMP manufacturing unit is responsible for process development and improvements, technology transfer and GMP manufacturing of Vyriad’s clinical and preclinical assets. The team members are fully qualified and GMP trained and are able to support preclinical PD and GMP activities at any time. They interface with the preclinical research teams, quality control and quality assurance teams to ensure timely supply of investigational medicines for preclinical and clinical needs.   

Position Overview

The Laboratory Manager is part of the PD and GMP manufacturing group and will report directly to the Director of Manufacturing. The lab manager will oversee and ensure efficient daily operations of the PD and R&D laboratories and activities, including purchasing, supplies and waste management, equipment and environmental controls. The lab manager is expected to be GMP trained and highly proficient in virology and virological methods, including virus propagation. The lab manager will train and mentor team members in virology and aseptic techniques while working in a controlled environment. The candidate will perform research activities in support of project needs. The candidate will work closely with the Director of Manufacturing to ensure programmatic goals and projects are met in compliance with applicable regulations. 

Key Responsibilities:

• Organizes and manages PD and R&D lab operations to ensure efficiency and compliance.
• Manages PD and GMP projects to ensure timely progress.
• Onboards, trains and mentors team members in virological methods and virus propagation.
• Works with supply chain to ensure adequate inventory to meet R&D, PD and GMP activities.
• Works with facility to ensure laboratory and equipment are maintained and calibrated.
• Complies with GMP and GDP training and qualifications as part of the GMP manufacturing team. 
• Performs research and analytical assays in support of project goals. 
• Contributes ideas for continuous quality and technical improvements of the team.

Other Responsibilities:

• Provides technical representation during internal and external audits.
• Keeps up to date with current technologies and trends in virus processing and purification.
• Perform routine tasks including lab housekeeping, equipment monitoring and maintenance.
• Practices and promotes safe work habits and adheres to safety procedures and guidelines.

Qualification Requirements:

• Minimum Bachelor’s degree in Biomedical, Chemical Engineering or Life Sciences with minimum 5 years relevant experience in virological methods and propagation of infectious viruses. 
• Experience with supervisory and lab management role is required.
• Experience with working in GMP and BSL2 regulated environments and compliance to federal regulations is required. 

Experience and skill requirement:

• Virology and working experience with infectious BSL2 or higher agents highly desirable. 
• Ability to apply scientific principles utilized to solve operational challenges and address routine production tasks.
• Excellent documentation skills, including comprehension, review and establishing SOPs, deviations and summary reports.